HMGN2 Antikörper

Produktnummer ABIN6989665

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch HMGN2 in WB, IHC (p) und IF (cc). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für HMGN2 Antikörper (ABIN6989665)

Target: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HMGN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Klon: 8H5

Produktdetails anti-HMGN2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic Peptide within N terminal human HMGN2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu HMGN2

Target: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Andere Bezeichnung: HMGN2

Hintergrund:

Synonyms: High mobility group (nonhistone chromosomal) protein 17 antibody, high mobility group nucleosomal binding domain 2 antibody, High mobility group nucleosome-binding domain-containing protein 2 antibody, High mobility group protein N2 antibody, HMG17 antibody, HMGN2 antibody, HMGN2_HUMAN antibody, MGC5629 antibody, Non histone chromosomal protein HMG 17 antibody, Non-histone chromosomal protein HMG-17 antibody, Nonhistone chromosomal protein HMG 17 antibody, nonhistone chromosomal protein hmg-17 antibody

Background: The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (15). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (13,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (13). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (13). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2).

Gen-ID: 3151

UniProt: P05204