TRBP Antikörper (AA 21-120)

Produktnummer ABIN6989190

Dieser Anti-TRBP Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von TRBP in IF (cc), IF (p), ICC, ELISA, IHC (fro) und IHC (p). Geeignet für Maus.

Kurzübersicht für TRBP Antikörper (AA 21-120) (ABIN6989190)

Target: TRBP (TARBP2P) (TAR (HIV-1) RNA Binding Protein 2 Pseudogene (TARBP2P))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRBP Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TRBP Antikörper

Bindungsspezifität: AA 21-120

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRBP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TRBP

Target: TRBP (TARBP2P) (TAR (HIV-1) RNA Binding Protein 2 Pseudogene (TARBP2P))

Andere Bezeichnung: TRBP

Hintergrund:

Synonyms: LOQS, Prbp, RISC loading complex subunit TARBP2, RISC-loading complex subunit tarbp2, TAR (HIV 1) RNA binding protein 2, TAR (HIV) RNA binding protein 2, TAR (HIV) RNA-binding protein TRBP1, TAR RNA Binding Protein 2, TAR RNA-binding protein 2, tarbp2, Trans-activation-responsive RNA-binding protein, TRBP, TRBP1, TRBP2, TRBP2_HUMAN.

Background: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Gen-ID: 6895

UniProt: Q15633

Pathways: Regulatorische RNA Pathways, Ribonucleoprotein Complex Subunit Organization