GIPC1 Antikörper (AA 171-270)
Kurzübersicht für GIPC1 Antikörper (AA 171-270) (ABIN6989016)
Target
Alle GIPC1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 171-270
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Kreuzreaktivität
- Maus, Ratte
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Homologie
- Human,Cow,Sheep
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human GIPC1?
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Isotyp
- IgG
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Applikationshinweise
- WB 1:300-5000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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Haltbarkeit
- 12 months
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- GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))
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Andere Bezeichnung
- GIPC1
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Hintergrund
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Synonyms: C19ORF3, Chromosome 19 open reading frame 3, GIPC, GLUT1 C terminal binding protein, GLUT1CBP, IGF 1 receptor interacting protein 1, IIP 1, IIP1, NIP, PDZ domain-containing protein GIPC1, Regulator of G protein signalling 19 interacting protein 1, RGS19 interacting protein 1, RGS19IP1, SEMCAP, SYNECTIIN, Tax interaction protein 2, TIP 2, GIPC1_HUMAN.
Background: GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.
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Gen-ID
- 10755
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UniProt
- O14908
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Pathways
- Dicarboxylic Acid Transport
Target
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