RUNX2 Antikörper (AA 201-300) (HRP)

Produktnummer ABIN6987651

Dieses Anti-RUNX2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RUNX2 in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für RUNX2 Antikörper (AA 201-300) (HRP) (ABIN6987651)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX2 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RUNX2 Antikörper (HRP)

Bindungsspezifität: AA 201-300

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RUNX2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Andere Bezeichnung: RUNX2

Hintergrund:

Synonyms: RUNX2_HUMAN, Runt-related Transcription Factor 2, CBF alpha 1, CBF-alpha-1, PEBP2-alpha A, CBFA1, CCD, CCD1, Cleidocranial dysplasia 1, Core binding factor, Core binding factor runt domain alpha subunit 1, Core binding factor subunit alpha 1, MGC120023, Oncogene AML 3, OSF 2, OSF2, OSF-2, Osteoblast specific transcription factor 2, OTTHUMP00000016533, PEA2 alpha A, PEA2aA, PEBP2 alpha A, PEBP2A1, PEBP2A2, PEBP2aA1, Polyomavirus enhancer binding protein 2 alpha A subunit, Runt domain, Runt related transcription factor 2, SL3 3 enhancer factor 1 alpha A subunit, SL3/AKV core binding factor alpha A subunit, AML3, CLCD.

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. [SUBUNIT] Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.

Gen-ID: 860

UniProt: Q13950