HMGN2 Antikörper (HRP)

Produktnummer ABIN6987583

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HMGN2 in IHC (p). Er zeigt eine Reaktivität gegenüber Ratte und Maus.

Kurzübersicht für HMGN2 Antikörper (HRP) (ABIN6987583)

Target: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGN2 Antikörper ist konjugiert mit HRP

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HMGN2 Antikörper (HRP)

Kreuzreaktivität: Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HMGN2/HMG17:2-60/90

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu HMGN2

Target: HMGN2 (High Mobility Group Nucleosomal Binding Domain 2 (HMGN2))

Andere Bezeichnung: HMGN2/HMG17

Hintergrund:

Synonyms: High mobility group (nonhistone chromosomal) protein 17, high mobility group nucleosomal binding domain 2, High mobility group nucleosome-binding domain-containing protein 2, High mobility group protein N2, HMG17, HMGN2, HMGN2_HUMAN, MGC5629, Non histone chromosomal protein HMG 17, Non-histone chromosomal protein HMG-17, Nonhistone chromosomal protein HMG 17, nonhistone chromosomal protein hmg-17.

Background: The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (15). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (13,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (13). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (13). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2). Post-translational modifications : Phosphorylation favors cytoplasmic localization. Similarity : Belongs to the HMGN family.

Gen-ID: 3151

UniProt: P05204