RRAGA + RRAGB (AA 231-313) Antikörper (HRP)

Produktnummer ABIN6987496

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RRAGA + RRAGB in ELISA, IHC (fro) und IHC (p). Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für RRAGA + RRAGB (AA 231-313) Antikörper (HRP) (ABIN6987496)

Target: RRAGA + RRAGB

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: HRP

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: AA 231-313

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RRAGA and RRAGB

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: RRAGA + RRAGB

Hintergrund:

Synonyms: FIP1, RAGA, FIP-1, RRAGB, Adenovirus E3 14.7 kDa-interacting protein 1, Rag A, RAg B, RagA, RAGB, Ras related GTP binding protein A, RRAGA_HUMAN, Ras-related GTP binding A? GTP-binding protein ragB, Rag B, RagB, Ras-related GTP-binding protein B, RRAGB, RRAGB_HUMAN..

Background: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Gen-ID: 10670

UniProt: Q7L523