KEAP1 Antikörper (AA 21-120) (AbBy Fluor® 750)
Kurzübersicht für KEAP1 Antikörper (AA 21-120) (AbBy Fluor® 750) (ABIN6982427)
Target
Alle KEAP1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 21-120
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Kreuzreaktivität
- Human, Maus
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Homologie
- Rat,Dog,Cow,Pig,Rabbit
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human KEAP1
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Isotyp
- IgG
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Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
- 12 months
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- KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
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Andere Bezeichnung
- KEAP1
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Hintergrund
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Synonyms: Cytosolic inhibitor of Nrf2, INrf 2, INrf2, Keap 1, KEAP1, KEAP1_HUMAN, Kelch like ECH associated protein 1, Kelch like protein 19, Kelch-like ECH-associated protein 1, Kelch-like protein 19, KIAA0132, KLHL 19, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454.
Background: Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
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Gen-ID
- 9817
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UniProt
- Q14145
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Pathways
- Maintenance of Protein Location
Target
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