RING1 Antikörper (C-Term)

Produktnummer ABIN6972601

Produktdetails anti-RING1 Antikörper

Target: RING1 (Ring Finger Protein 1 (RING1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RING1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: RING1 (Ring Finger Protein 1) constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. RING1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a peptide within the C-terminal region of human RING1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu RING1

Target: RING1 (Ring Finger Protein 1 (RING1))

Andere Bezeichnung: RING1 (RING1 Produkte)

Synonyme: RING1A antikoerper, RNF1 antikoerper, Ring1A antikoerper, bap-1 antikoerper, bap1 antikoerper, ding antikoerper, hipi3 antikoerper, ring1a antikoerper, ring1b antikoerper, ring2 antikoerper, rnf1 antikoerper, rnf2-a antikoerper, ring1 antikoerper, ring1b-B antikoerper, rnf2-b antikoerper, ring finger protein 1 antikoerper, ring finger protein 1 S homeolog antikoerper, ring finger protein 1 L homeolog antikoerper, RING1 antikoerper, Ring1 antikoerper, ring1.S antikoerper, ring1.L antikoerper

Molekulargewicht: 50 kDa

NCBI Accession: NP_002922