PRMT5 Antikörper (N-Term)

Produktnummer ABIN6972554

Produktdetails anti-PRMT5 Antikörper

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ChIP DNA-Sequencing (ChIP-seq)

Produktmerkmale: PRMT5 (Protein Arginine Methyltransferase 5, also known as JBP1, Janus Binding Protein 1) is a type II arginine methyltransferase, a protein that transfers methyl groups to the arginine residues of substrate proteins. Arginine methylation is a common post-translational modification of histones and other cellular proteins. PRMT5 symmetrically dimethylates histone H2A Arg3, H3 Arg8 and H4 Arg3. It also methylates PIWI proteins which regulate small non-coding RNAs and snRNPs, regulating snRNP core particle assembly. PRMT5 functions as a co-repressor of transcription and is recruited by a number of DNA binding proteins and transcriptional repressor complexes. It is present both in the nucleus and the cytoplasm. It also interacts with COPR5, JAK2, PRDM1 and RPS10. PRMT5 antibody (pAb) was raised in a Rabbit host. It has been validated for use in ChIP-Seq and Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This PRMT5 antibody was raised against a peptide corresponding to amino acids within the N-terminal region of human PRMT5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu PRMT5

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Andere Bezeichnung: PRMT5 (PRMT5 Produkte)

Synonyme: HRMT1L5 antikoerper, IBP72 antikoerper, JBP1 antikoerper, SKB1 antikoerper, SKB1Hs antikoerper, Jbp1 antikoerper, Skb1 antikoerper, si:zc14a17.2 antikoerper, skb1 antikoerper, wu:fb95f10 antikoerper, zgc:110669 antikoerper, hsl7 antikoerper, DDBDRAFT_0187422 antikoerper, DDBDRAFT_0235403 antikoerper, DDB_0187422 antikoerper, DDB_0235403 antikoerper, NV18830 antikoerper, jbp1 antikoerper, ibp72 antikoerper, skb1hs antikoerper, hrmt1l5 antikoerper, protein arginine methyltransferase 5 antikoerper, protein arginine N-methyltransferase 5 antikoerper, protein arginine methyltransferase 5 L homeolog antikoerper, putative arginine N-methyltransferase, type II antikoerper, Skb1 family protein antikoerper, Protein arginine N-methyltransferase 5 antikoerper, PRMT5 antikoerper, Prmt5 antikoerper, prmt5 antikoerper, prmt5.L antikoerper, LOC100115766 antikoerper, prmt-5 antikoerper

Molekulargewicht: 75 kDa

NCBI Accession: NP_006100

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development