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H2AFV Antikörper (C-Term)

Der Maus Monoklonal Anti-H2AFV-Antikörper wurde für WB und ChIP validiert. Er ist geeignet, H2AFV in Proben von Drosophila melanogaster zu detektieren.
Produktnummer ABIN6971793

Kurzübersicht für H2AFV Antikörper (C-Term) (ABIN6971793)

Target

Alle H2AFV Antikörper anzeigen
H2AFV (H2A Histone Family, Member V (H2AFV))

Reaktivität

  • 15
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Drosophila melanogaster

Wirt

  • 12
  • 5
Maus

Klonalität

  • 12
  • 5
Monoklonal

Konjugat

  • 13
  • 2
  • 1
  • 1
Dieser H2AFV Antikörper ist unkonjugiert

Applikation

  • 10
  • 7
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Klon

10E9-D1
  • Bindungsspezifität

    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Produktmerkmale

    The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H2A.Z (H2AZ, H2AFZ) is a histone H2A variant, a protein similar to canonical H2A but with different molecular identity and unique functions. H2A.Z is highly conserved during evolution. It plays an important role in basic cellular mechanisms such as gene activation, chromosome segregation, heterochromatic silencing and progression through the cell cycle.In Drosophila, the H2A variant corresponding to H2AZ is H2Av. H2Av is an essential protein in Drosophila and has been implicated in both activation and repression of transcription. H2Av is localized to centromeric heterochromatin in Drosophila and flies lacking H2Av have reduced levels of heterochromatin components at the centromeres. However, H2Av nucleosome distribution throughout the rest of the Drosophila genome correlates with genes that have an open and uniform chromatin architecture at promoter regions. Histone H2Av antibody (mAb) (Clone 10E9.D1) was raised in a Mouse host. It has been validated for use in Chromatin Immunoprecipitation and Western blot, it has been shown to react with Drosophila samples.

    Aufreinigung

    Protein A Chromatography

    Immunogen

    This antibody was raised against a peptide in the C-terminus of the Drosophila melanogaster Histone variant H2Av.

    Isotyp

    IgG2a
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target

    H2AFV (H2A Histone Family, Member V (H2AFV))

    Andere Bezeichnung

    Histone H2Av

    Molekulargewicht

    15 kDa

    NCBI Accession

    NP_524519
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