Estrogen Receptor alpha Antikörper (C-Term)

Produktnummer ABIN6971631

Der Maus Monoklonal Anti-Estrogen Receptor alpha-Antikörper wurde für WB, IP und ChIP validiert. Er ist geeignet, Estrogen Receptor alpha in Proben von Human zu detektieren.

Kurzübersicht für Estrogen Receptor alpha Antikörper (C-Term) (ABIN6971631)

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Estrogen Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Klon: F3

Produktdetails anti-Estrogen Receptor alpha Antikörper

Bindungsspezifität: C-Term

Produktmerkmale: ER-a (estrogen receptor a) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. ER-a localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer and osteoporosis. Estrogen Receptor alpha antibody (mAb) (Clone F3) was raised in a Mouse host. It has been validated for use in Chromatin Immunoprecipitation, Immunoprecipitation and Western blot, it has been shown to react with Human samples.

Aufreinigung: Protein G Chromatography

Immunogen: This ER-alpha antibody was raised against a peptide within the C-terminal region of human Estrogen Receptor alpha.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Andere Bezeichnung: Estrogen Receptor α

Molekulargewicht: 66 kDa

NCBI Accession: NP_000116

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly