Catalase Antikörper (AA 23-226)

Produktnummer ABIN6961050

Der Kaninchen Monoklonal Anti-Catalase-Antikörper wurde für ELISA, IP, IF und FACS validiert. Er ist geeignet, Catalase in Proben von Human zu detektieren.

Kurzübersicht für Catalase Antikörper (AA 23-226) (ABIN6961050)

Target: Catalase (CAT)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Catalase Antikörper ist unkonjugiert

Applikation: ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: DM9

Produktdetails anti-Catalase Antikörper

Bindungsspezifität: AA 23-226

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human CS1 (Ser23-Met226) (ABIN6961075) produced by using human HEK293 cells

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cyt  1/100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA, 0.1 % Procline 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Details zu Catalase

Target: Catalase (CAT)

Andere Bezeichnung: CS1

Hintergrund: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).

Molekulargewicht: 37 kDa

Gen-ID: 57823

UniProt: Q9NQ25

Pathways: Cellular Glucan Metabolic Process, Cell RedoxHomeostasis, Photoperiodism