Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Rekombinanter SARS-CoV-2 Spike S1 Antikörper (Biotin)

Dieses Anti-SARS-CoV-2 Spike S1-Antikörper ist ein Human Monoklonal-Antikörper zur Detektion von SARS-CoV-2 Spike S1 in ELISA. Geeignet für SARS Coronavirus-2 (SARS-CoV-2).
Produktnummer ABIN6953155

Kurzübersicht für Rekombinanter SARS-CoV-2 Spike S1 Antikörper (Biotin) (ABIN6953155)

Target

Alle SARS-CoV-2 Spike S1 Antikörper anzeigen
SARS-CoV-2 Spike S1

Antikörpertyp

Recombinant Antibody

Fragment

scFv fragment

Reaktivität

  • 45
  • 6
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
SARS Coronavirus-2 (SARS-CoV-2)

Wirt

  • 17
  • 10
  • 9
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Klonalität

  • 33
  • 8
  • 5
Monoklonal

Konjugat

  • 41
  • 2
  • 1
  • 1
  • 1
Dieser SARS-CoV-2 Spike S1 Antikörper ist konjugiert mit Biotin

Applikation

  • 46
  • 10
  • 8
  • 6
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
ELISA

Klon

H6
  • Produktmerkmale

    Recombinant anti-SARS-CoV-2 spike Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
    Mouse scFv fusion with human IgG1 Fc
    AA 16-685

    Aufreinigung

    Affinity-chromatography

    Immunogen

    Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa)

    Isotyp

    IgG1
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
  • Target

    SARS-CoV-2 Spike S1

    Substanzklasse

    Viral Protein

    Hintergrund

    Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.

    Gen-ID

    43740568

    UniProt

    P0DTC2
Sie sind hier:
Chat with us!