CTCF Antikörper

Produktnummer ABIN6952397

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CTCF in WB, ELISA, IF, ChIP und ChIP-seq. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CTCF Antikörper (ABIN6952397)

Target: CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTCF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Güteklasse: ChIP-seq Grade

Produktdetails anti-CTCF Antikörper

Spezifität: Polyclonal antibody raised in rabbit against human CTCF (CCCTC-Binding Factor), using 4 KLH coupled peptides.

Kreuzreaktivität: Maus

Aufreinigung: Peptide affinity purified

Immunogen: synthetic peptide

Anwendungsinformationen

Applikationshinweise: ChIP/ChIP-seq 1 μg:ChIP
ELISA 1:10,000
WB 1:1,000
IF 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.5 μg/μL

Buffer: PBS, 0.05 % azide, 0.05 % ProClin300

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu CTCF

Target: CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

Andere Bezeichnung: CTCF

Hintergrund: CTCF (UniProt/Swiss-Prot entry P49711) is a transcriptional regulator protein with 11 highly conserved zinc finger domains. By using different combinations of the zinc finger domains, CTCF can bind to different DNA sequences and proteins. As such it can act as both a transcriptional repressor and a transcriptional activator. By binding to transcriptional insulator elements, CTCF can also block communication between enhancers and upstream promoters, thereby regulating imprinted gene expression. CTCF also binds to the H19 imprinting control region and mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Mutations in the CTCF gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumor.

UniProt: P49711