p300 Antikörper

Produktnummer ABIN6952378

Der Maus Monoklonal anti-p300 Antikörper (ABIN6952378) detektiert spezifisch p300 in ChIP und ChIP-seq. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für p300 Antikörper (ABIN6952378)

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser p300 Antikörper ist unkonjugiert

Applikation: Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Güteklasse: ChIP-seq Grade

Produktdetails anti-p300 Antikörper

Spezifität: Monoclonal antibody raised in mouse against human p300 (E1A Binding Protein P300) by DNA immunization in which the C-terminal part of the protein was cloned and expressed.

Aufreinigung: Protein A purified

Immunogen: DNA immunization

Isotyp: IgG3

Anwendungsinformationen

Applikationshinweise: ChIP/ChIP-seq 5 μg:ChIP

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.9 μg/μL

Buffer: PBS, 0.05 % azide, 0.05 % ProClin300

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu p300

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Andere Bezeichnung: p300

Hintergrund: P300 (UniProt/Swiss-Prot entry Q09472) is a histone acetyltransferase that regulates transcription via chromatin remodelling. As such it is important for cell proliferation and differentiation. p300 is able to acetylate all four core histones in nucleosomes. Acetylation of histones is associated with transcriptional activation. p300 also acetylates non-histone proteins such as HDAC1 leading to its inactivation and modulation of transcription. It has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in the p300 gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

UniProt: Q09472

Pathways: p53 Signalweg, Notch Signalweg, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size