HIST1H4A Antikörper (acLys16)

Produktnummer ABIN6946913

Dieses Anti-HIST1H4A-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von HIST1H4A in WB, FACS, IHC (p), IF (cc) und IF (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für HIST1H4A Antikörper (acLys16) (ABIN6946913)

Target: HIST1H4A (Histone Cluster 1, H4a (HIST1H4A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HIST1H4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Klon: 2G2

Produktdetails anti-HIST1H4A Antikörper

Bindungsspezifität: acLys16

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic peptide corresponding to human histone H4 (acetyl K16).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu HIST1H4A

Target: HIST1H4A (Histone Cluster 1, H4a (HIST1H4A))

Andere Bezeichnung: HIST1H4A

Hintergrund:

Synonyms: Histone H4, HIST1H4A, acetyl-Histone H4 (Lys16), H4K16Ac, histone cluster 4 H4, Histone H4 Acetylated on Lysine 16, H4 histone family

Background: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H4 are known to be acetylated on Lysine 5, 8, 12, and 16. Acetylations are important for the regulation of histone deposition, transcriptional activation, DNA replication and repair. Hyper-acetylation of the histone tails is shown to neutralize positive charge and weakens histone-DNA and nucleosome-nucleosome interactions that destabilizes chromatin structure and increases the accessibility of DNA to various DNA-binding proteins.

Gen-ID: 121504

UniProt: P62805