Rekombinanter WNK1 Antikörper (AA 100-200)

Produktnummer ABIN6945392

Der Kaninchen Monoklonal anti-WNK1 Antikörper (ABIN6945392) detektiert spezifisch WNK1 in WB, IHC (p), IF und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Rekombinanter WNK1 Antikörper (AA 100-200) (ABIN6945392)

Target: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser WNK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-WNK1 Antikörper

Bindungsspezifität: AA 100-200

Verwendungszweck: WNK1 Recombinant Antibody

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic peptide within Human WNK1 aa 100-200 (Cysteine residue).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000), IHC-P(1:20-100), IHC-F(1:200-400), IF()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu WNK1

Target: WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))

Andere Bezeichnung: WNK1

Hintergrund:

Synonyms: Serine/threonine-protein kinase WNK1, Erythrocyte 65 kDa protein, Kinase deficient protein, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, p65, hWNK1, WNK1, HSN2, KDP, KIAA0344, PRKWNK1

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.

Gen-ID: 65125

UniProt: Q9H4A3