Versican Antikörper

Produktnummer ABIN6945282

Produktdetails anti-Versican Antikörper

Target: Versican (Vcan)

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Versican Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human Versican aa 3100-3300

Klon: 2G2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Versican

Target: Versican (Vcan)

Andere Bezeichnung: Versican (Vcan Produkte)

Synonyme: br146 antikoerper, cspg2 antikoerper, cspg2a antikoerper, sb:cb63 antikoerper, versican antikoerper, CSPG2 antikoerper, Cspg2 antikoerper, wgn antikoerper, ervr antikoerper, pg-m antikoerper, wgn1 antikoerper, Xversican antikoerper, dcan antikoerper, cspg2b antikoerper, fb99b07 antikoerper, wu:fb99b07 antikoerper, ERVR antikoerper, GHAP antikoerper, PG-M antikoerper, WGN antikoerper, WGN1 antikoerper, 5430420N07Rik antikoerper, 9430051N09 antikoerper, DPEAAE antikoerper, NG2 antikoerper, PG-M(V0) antikoerper, PG-M(V1) antikoerper, hdf antikoerper, versican a antikoerper, versican antikoerper, versican b antikoerper, vcana antikoerper, VCAN antikoerper, Vcan antikoerper, vcan antikoerper, vcanb antikoerper

Hintergrund:

Synonyms: Versican core protein, Chondroitin sulfate proteoglycan core protein 2, Glial hyaluronate-binding protein, Large fibroblast proteoglycan, PG-M, Chondroitin sulfate proteoglycan 2, GHAP, VCAN, CSPG2.

Background: Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a lectin-like sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycosaminoglycan chains. Accumulation around smooth muscle cells in lesions of atherosclerosis, suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may facilitate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels. The human versican gene maps to chromosome 5q14.3.

Gen-ID: 1462

UniProt: P13611

Pathways: Glycosaminoglycan Metabolic Process