SDCBP Antikörper
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- Target Alle SDCBP Antikörper anzeigen
- SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser SDCBP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human
- Aufreinigung
- Purified by Protein A.
- Immunogen
- Recombinant protein within human Syntenin aa 1-200.
- Klon
- 2G6
- Isotyp
- IgG
- Top Product
- Discover our top product SDCBP Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg) - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))
- Andere Bezeichnung
- SDCBP (SDCBP Produkte)
- Synonyme
- MDA-9 antikoerper, ST1 antikoerper, SYCL antikoerper, TACIP18 antikoerper, Sycl antikoerper, syntenin-1 antikoerper, mda-9 antikoerper, st1 antikoerper, sycl antikoerper, tacip18 antikoerper, MGC81274 antikoerper, syntenin antikoerper, wu:fc51c03 antikoerper, wu:fk31e01 antikoerper, zgc:55679 antikoerper, zgc:77716 antikoerper, sb:eu862 antikoerper, si:dkey-235k4.1 antikoerper, syndecan binding protein antikoerper, syndecan binding protein L homeolog antikoerper, syndecan binding protein (syntenin) 2 antikoerper, syndecan binding protein (syntenin) antikoerper, SDCBP antikoerper, Sdcbp antikoerper, sdcbp.L antikoerper, LOC732879 antikoerper, sdcbp2 antikoerper, sdcbp antikoerper
- Hintergrund
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Synonyms: Syntenin-1, Melanoma differentiation-associated protein 9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Scaffold protein Pbp1, Syndecan-binding protein 1, MDA-9, TACIP18, SDCBP, MDA9, SYCL
Background: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer type. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
- Gen-ID
- 6386
- UniProt
- O00560
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