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PP2A alpha/beta Antikörper

Der Kaninchen Monoklonal Anti-PP2A alpha/beta-Antikörper wurde für WB, IF (cc), IHC (p) und IHC validiert. Er ist geeignet, PP2A alpha/beta in Proben von Human, Maus, Ratte und Zebrafisch (Danio rerio) zu detektieren.
Produktnummer ABIN6944644

Kurzübersicht für PP2A alpha/beta Antikörper (ABIN6944644)

Target

PP2A alpha/beta (PP2A A/B)

Reaktivität

  • 43
  • 27
  • 25
  • 7
  • 1
Human, Maus, Ratte, Zebrafisch (Danio rerio)

Wirt

  • 41
  • 2
  • 1
Kaninchen

Klonalität

  • 34
  • 10
Monoklonal

Konjugat

  • 8
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PP2A alpha/beta Antikörper ist unkonjugiert

Applikation

  • 37
  • 26
  • 26
  • 14
  • 11
  • 6
  • 6
  • 2
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)

Klon

11F10
  • Kreuzreaktivität

    Human, Maus, Ratte, Zebrafisch (Danio rerio)

    Aufreinigung

    Purified by Protein A.

    Immunogen

    Human PP2A alpha + beta aa 250-350

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    PP2A alpha/beta (PP2A A/B)

    Andere Bezeichnung

    PP2A alpha + beta

    Hintergrund

    Synonyms: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-alpha, RP-C, PPP2CA, PP2A-beta, PPP2CB

    Background: The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.

    UniProt

    P62714, P67775
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