Reticulon 4 Antikörper

Produktnummer ABIN6944299

Produktdetails anti-Reticulon 4 Antikörper

Target: Reticulon 4 (RTN4)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Reticulon 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within human Nogo aa 1-200

Klon: 7A12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Reticulon 4

Target: Reticulon 4 (RTN4)

Andere Bezeichnung: Nogo-B (RTN4 Produkte)

Synonyme: ASY antikoerper, NI220/250 antikoerper, NOGO antikoerper, NOGO-A antikoerper, NOGOC antikoerper, NSP antikoerper, NSP-CL antikoerper, Nbla00271 antikoerper, Nbla10545 antikoerper, Nogo-B antikoerper, Nogo-C antikoerper, RTN-X antikoerper, RTN4-A antikoerper, RTN4-B1 antikoerper, RTN4-B2 antikoerper, RTN4-C antikoerper, RTN4-Cw antikoerper, DKFZp459C0314 antikoerper, 1110020G17Rik antikoerper, AA407876 antikoerper, AA409940 antikoerper, AA960376 antikoerper, C130026I10Rik antikoerper, NgA antikoerper, Nogo-A antikoerper, mKIAA0886 antikoerper, mKIAA4153 antikoerper, NI-250 antikoerper, Nogo antikoerper, Vp20 antikoerper, r antikoerper, rat N antikoerper, rat NogoA antikoerper, reticulon-4 antikoerper, nogo antikoerper, rtn4 antikoerper, wu:fb17a02 antikoerper, wu:fb22f12 antikoerper, wu:fd61a07 antikoerper, zgc:92163 antikoerper, reticulon 4 antikoerper, reticulon 4a antikoerper, RTN4 antikoerper, rtn4 antikoerper, Rtn4 antikoerper, rtn4a antikoerper

Hintergrund:

Synonyms: Reticulon-4B, RTN 4B, Foocen-M, RTN-xS, Neurite outgrowth inhibitor, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog,

Background: Reticulon-4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. It regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 is also Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Isoform 2 of the Reticulon-4 protein, also known as Nogo-B or Reticulon-4B, reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 (Nogo-B) and isoform 3 (Nogo-C) inhibit BACE1 activity and amyloid precursor protein processing. Nogo-B is mainly localized primarily in the endoplasmic reticulum (ER), where it participates in the maintenance of ER tubular shape and functions. Nogo-B is expressed in most tissues and is associated with diverse processes such as vascular remodeling, liver regeneration, liver cirrhosis, pulmonary hypertension, and inflammatory bowel disease.

Gen-ID: 57142

UniProt: Q9NQC3

Pathways: Neurotrophin Signalübertragung, Regulation of Cell Size, SARS-CoV-2 Protein Interaktom