MYST1 Antikörper (AA 351-450)

Produktnummer ABIN6944204

Produktdetails anti-MYST1 Antikörper

Target: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Bindungsspezifität: AA 351-450

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYST1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYST1/KAT8

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MYST1

Target: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Andere Bezeichnung: MYST1/KAT8 (KAT8 Produkte)

Synonyme: myst1 antikoerper, wu:fb22g02 antikoerper, wu:fj22d09 antikoerper, zgc:66387 antikoerper, Myst1 antikoerper, MOF antikoerper, MYST1 antikoerper, ZC2HC8 antikoerper, hMOF antikoerper, 2010203C02Rik antikoerper, 5830450F21Rik antikoerper, D7Ertd629e antikoerper, K(lysine) acetyltransferase 8 antikoerper, lysine acetyltransferase 8 antikoerper, kat8 antikoerper, KAT8 antikoerper, Kat8 antikoerper

Hintergrund:

Synonyms: EC 2.3.1.48, Histone acetyltransferase KAT8, Histone acetyltransferase MYST1, hMOF, K(lysine) acetyltransferase 8, KAT 8, Lysine acetyltransferase 8, MOF, MOZ, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST 1, MYST histone acetyltransferase 1, myst protein 1, MYST-1, MYST1, MYST1_HUMAN, Ortholog of Drosophila males absent on the first (MOF), Probable histone acetyltransferase MYST1, SAS2 and TIP60 protein 1, SAS2, SAS3, TIP60 protein 1, YBF2, YBF2/SAS3.

Background: Dosage compensation ensures that males with a single X chromosome and females with two X chromosomes have the same amount of most X-linked gene products. In Drosophila, this is acheived by enhancing the level of transcription of the X chromosome in males. Proteins such as maleless, male specific lethal 1, 2 and 3, and males absent on the first (MOF) form a dosage compensation complex (DCC) that is required for the twofold increase of transcription of the male X chromosome. The DCC is preferentially associated with many sites on the X chromosome in somatic cells of males. The binding of the DCC to the X chromosome is dependent upon histone 4 acetylation at lysine 16, which is accomplished by MOF. In mammals, MOF (also designated hMOF, MYST1, or MOZ) belongs to the MYST family of histone acetyl transferases which are characterized by a unique C2HC-type zinc finger close to their HAT domains. MOF utilizes the zinc finger domain to contact the globular part of the nucleosome as well as the histone H4 N-terminal tail substrate. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone acetyltransferases.

Gen-ID: 84148

UniProt: Q9H7Z6