MC1 Receptor Antikörper (AA 181-280) (HRP)

Produktnummer ABIN6944034

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MC1 Receptor in ELISA, WB, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MC1 Receptor Antikörper (AA 181-280) (HRP) (ABIN6944034)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC1 Receptor Antikörper ist konjugiert mit HRP

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MC1 Receptor Antikörper (HRP)

Bindungsspezifität: AA 181-280

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MC1 Receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Andere Bezeichnung: MC1 Receptor

Hintergrund:

Synonyms: MC1 Receptor, CMM5, MC1-R, MC-1R, MC1R, Melanocortin 1 receptor, Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Melanotropin receptor, MSH-R, MSHR, MSHR_HUMAN, SHEP2.

Background: This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Gen-ID: 4157

UniProt: Q01727

Pathways: cAMP Metabolic Process, Feeding Behaviour