JNK1,JNK3 Antikörper

Produktnummer ABIN6943854

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch JNK1,JNK3 in IF (cc) und WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für JNK1,JNK3 Antikörper (ABIN6943854)

Target: JNK1,JNK3

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Western Blotting (WB)

Klon: 4T6

Produktdetails

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Human JNK1 + JNK3 aa 1-400

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Antigendetails

Target: JNK1,JNK3

Andere Bezeichnung: JNK1+JNK3

Hintergrund:

Synonyms: c Jun N terminal kinase 3 antibody, c Jun N-terminal kinase 1 antibody, JNK 46 antibody, JNK antibody, JNK1 antibody, JNK1A2 antibody, JNK21B1/2 antibody, JNK3 alpha protein kinase antibody, JNK3 antibody, JNK3A antibody, JUN N terminal kinase antibody, MAP kinase 10 antibody, MAP kinase 8 antibody MAP kinase p49 3F12 antibody, MAPK 10 antibody, MAPK10 antibody, MAPK8 antibody, Mitogen activated protein kinase 10 antibody, Mitogen activated protein kinase 8 antibody, Mitogen activated protein kinase 8 isoform JNK1 alpha1 antibody, Mitogen activated protein kinase 8 isoform JNK1 beta2 antibody, p493F12 antibody, p54bSAPK antibody, PRKM10 antibody, PRKM8 antibody, SAPK1 antibody, SAPK1b antibody, SAPK1c antibody

Background: c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83 % amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).

UniProt: P45983, P53779