EXOSC4 Antikörper (AA 51-150) (Biotin)

Produktnummer ABIN6943360

Der Kaninchen Polyklonal Anti-EXOSC4-Antikörper wurde für ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, EXOSC4 in Proben von Maus zu detektieren.

Kurzübersicht für EXOSC4 Antikörper (AA 51-150) (Biotin) (ABIN6943360)

Target: EXOSC4 (Exosome Component 4 (EXOSC4))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXOSC4 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-EXOSC4 Antikörper (Biotin)

Bindungsspezifität: AA 51-150

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXOSC4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu EXOSC4

Target: EXOSC4 (Exosome Component 4 (EXOSC4))

Andere Bezeichnung: EXOSC4

Hintergrund:

Synonyms: EXOSC 4, Exosome complex component RRP41, Exosome complex exonuclease RRP41, Exosome component 4, Exosome component Rrp41, FLJ20591, hRrp41p, p12A, EXOS4_HUMAN, Ribosomal RNA processing protein 41, RRP 41, RRP41, RRP41A, Rrp41p, SKI 6, SKI6, Ski6p.

Background: The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3 to 5 exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3 region. EXOSC4 (exosome component 4), also known as SKI6, RRP41 or p12A, is a 245 amino acid protein that localizes to both the nucleus and the cytoplasm and shares 96 % sequence identity with its mouse counterpart. Functioning as a component of the exosome complex, EXOSC4 exhibits 3'-5' exonuclease activity and is required for the 3'-processing of 7S pre-RNA to mature 5.8S rRNA. The gene encoding EXOSC4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Gen-ID: 54512

UniProt: Q9NPD3