DNMT3A Antikörper

Produktnummer ABIN6943093

Der Kaninchen Polyklonal Anti-DNMT3A-Antikörper wurde für WB, ELISA, IP und ChIP-seq validiert. Er ist geeignet, DNMT3A in Proben von Human zu detektieren.

Kurzübersicht für DNMT3A Antikörper (ABIN6943093)

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), ChIP DNA-Sequencing (ChIP-seq)

Produktdetails anti-DNMT3A Antikörper

Kreuzreaktivität: Human

Aufreinigung: Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.

Immunogen: Polyclonal antibody raised in rabbit against human DNMT3A, (DNA methyltransferase 3A), using a KLH-conjugated synthetic peptide corresponding to amino acids 44-58

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IP(1-2 μg)
ChIP-seq()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.75 μg/μL

Buffer: PBS with 0.05 % sodium azide and 0.05 % Proclin300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu DNMT3A

Target: DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

Andere Bezeichnung: DNMT3A

Hintergrund:

Synonyms: DNMT3A2, TBRS

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

Gen-ID: 1788

UniProt: Q9Y6K1