CASP14 Antikörper (AA 100-200)
Kurzübersicht für CASP14 Antikörper (AA 100-200) (ABIN6942355)
Target
Alle CASP14 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 100-200
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Verwendungszweck
- Caspase-14 (8C4) Monoclonal Antibody
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Kreuzreaktivität
- Human, Maus, Ratte
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Aufreinigung
- Purified by Protein A.
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Immunogen
- Human Caspase-14 aa 100-200
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Isotyp
- IgG
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Applikationshinweise
- WB(1:300-5000), FCM(1:200-400), IHC-P(1:50-200), IF(ICC)(1:50-200), IHC()
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- Lot specific
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Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C for 12 months.
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Haltbarkeit
- 12 months
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- CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
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Andere Bezeichnung
- Caspase-14
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Hintergrund
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Synonyms: Caspase-14, CASP-14, CASP14
Background: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
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Gen-ID
- 23581
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UniProt
- P31944
Target
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