Aryl Hydrocarbon Receptor Antikörper

Produktnummer ABIN6942132

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch Aryl Hydrocarbon Receptor in WB, IHC (p) und IF (cc). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für Aryl Hydrocarbon Receptor Antikörper (ABIN6942132)

Target: Aryl Hydrocarbon Receptor (AHR)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Aryl Hydrocarbon Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Klon: 3C7

Produktdetails anti-Aryl Hydrocarbon Receptor Antikörper

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified by Protein A.

Immunogen: Human Aryl hydrocarbon Receptor aa 600-800

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Aryl Hydrocarbon Receptor

Target: Aryl Hydrocarbon Receptor (AHR)

Andere Bezeichnung: Aryl hydrocarbon Receptor

Hintergrund:

Synonyms: Class E basic helix-loop-helix protein 76, Ah receptor, AhR, bHLHe76

Background: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).

Gen-ID: 196

UniProt: P35869

Pathways: Regulation of Cell Size