ADAM10 Antikörper

Produktnummer ABIN6942048

Produktdetails anti-ADAM10 Antikörper

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ADAM10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: C terminus human ADAM10

Klon: 4C3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Andere Bezeichnung: ADAM10 (ADAM10 Produkte)

Synonyme: ADAM10 antikoerper, Adam10 antikoerper, adam10 antikoerper, wu:fc03d12 antikoerper, ad10 antikoerper, cd156c antikoerper, kuz antikoerper, kuzbanian antikoerper, madm antikoerper, xadam10 antikoerper, ADAM-10 antikoerper, ADAM 10 antikoerper, AD10 antikoerper, CD156c antikoerper, HsT18717 antikoerper, MADM antikoerper, 1700031C13Rik antikoerper, LOC100219653 antikoerper, zgc:64203 antikoerper, ADAM metallopeptidase domain 10 antikoerper, ADAM metallopeptidase domain 10a antikoerper, ADAM metallopeptidase domain 10 S homeolog antikoerper, a disintegrin and metallopeptidase domain 10 antikoerper, ADAM metallopeptidase domain 10b antikoerper, ADAM10 antikoerper, Adam10 antikoerper, adam10a antikoerper, adam10.S antikoerper, adam10b antikoerper

Hintergrund:

Synonyms: Disintegrin and metalloproteinase domain-containing protein 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM 10

Background: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Gen-ID: 102

UniProt: O14672

Pathways: Notch Signalweg, EGFR Signaling Pathway