CD28 Antikörper

Produktnummer ABIN6941133

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD28 in FACS, IF und Func. Er zeigt eine Reaktivität gegenüber Human, Maus, Rind (Kuh), Schwein und Schaf.

Kurzübersicht für CD28 Antikörper (ABIN6941133)

Target: CD28

Reaktivität: Human, Maus, Rind (Kuh), Schwein, Schaf

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD28 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Klon: 204-12

Produktdetails anti-CD28 Antikörper

Spezifität: Recognizes a glycoprotein of 44-88 kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

Aufreinigung: Purified by Protein A/G

Immunogen: Stimulated human leucocytes

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Jurkat cells. Human lymph nodes and tonsils.

Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL) Functional Studies (Order Ab without BSA & Azide), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu CD28

Target: CD28

Andere Bezeichnung: CD28

Molekulargewicht: 44kDa (monomer), 88kDa (dimer)

Gen-ID: 940

UniProt: P10747

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response