CD8 alpha Antikörper (C-Term, Cytoplasmic Domain)

Produktnummer ABIN6941082

Dieses Anti-CD8 alpha-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD8 alpha in ELISA und Coat. Geeignet für Human.

Kurzübersicht für CD8 alpha Antikörper (C-Term, Cytoplasmic Domain) (ABIN6941082)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Produktdetails anti-CD8 alpha Antikörper

Bindungsspezifität: C-Term, Cytoplasmic Domain

Immunogen: Recombinant fragment from C-terminal cytoplasmic domain of alpha chain of human CD8 (exact sequence is proprietary).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Positive Control: HuT78 or hPBL. Tonsil.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 200 µg/mL of antibody Purified from rabbit anti-serum by Protein A chromatography. Supplied in 10 mM PBS, pH 7.4 with 0.05 % BSA and 0.05 % sodium azide. Contact us if you require this antibody in a different format.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Andere Bezeichnung: CD8A

Hintergrund: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Molekulargewicht: 32kDa

Gen-ID: 925

UniProt: P01732

Pathways: T-Zell Rezeptor Signalweg