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ACTN2 Antikörper (AA 557-692)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ACTN2 in IHC und StM. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6940978

Kurzübersicht für ACTN2 Antikörper (AA 557-692) (ABIN6940978)

Target

Alle ACTN2 Antikörper anzeigen
ACTN2 (Actinin, alpha 2 (ACTN2))

Reaktivität

  • 110
  • 65
  • 39
  • 8
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
Human

Wirt

  • 81
  • 61
Maus

Klonalität

  • 74
  • 68
Monoklonal

Konjugat

  • 61
  • 12
  • 6
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ACTN2 Antikörper ist unkonjugiert

Applikation

  • 114
  • 82
  • 50
  • 19
  • 14
  • 13
  • 13
  • 13
  • 11
  • 11
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), Staining Methods (StM)

Klon

ACTN2-3291
  • Bindungsspezifität

    • 56
    • 15
    • 9
    • 9
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 557-692

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    A recombinantfragment (aa557-692) ofhuman ACTN2 protein(exact sequence is proprietary)

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Positive Control: Skeletal orCardiac Muscle.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    ACTN2 (Actinin, alpha 2 (ACTN2))

    Andere Bezeichnung

    ACTN2

    Hintergrund

    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

    Molekulargewicht

    103kDa

    Gen-ID

    88

    UniProt

    P35609

    Pathways

    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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