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Rekombinanter PAX8 Antikörper (AA 60-261)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch PAX8 in IHC, StM und ISt. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6940926

Kurzübersicht für Rekombinanter PAX8 Antikörper (AA 60-261) (ABIN6940926)

Target

Alle PAX8 Antikörper anzeigen
PAX8 (Paired Box 8 (PAX8))

Antikörpertyp

Recombinant Antibody

Reaktivität

  • 117
  • 49
  • 42
  • 20
  • 20
  • 7
  • 6
  • 5
  • 4
  • 2
  • 2
  • 1
Human

Wirt

  • 81
  • 37
  • 1
Maus

Klonalität

  • 62
  • 57
Monoklonal

Konjugat

  • 66
  • 8
  • 6
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PAX8 Antikörper ist unkonjugiert

Applikation

  • 90
  • 39
  • 35
  • 31
  • 28
  • 19
  • 14
  • 12
  • 11
  • 10
  • 6
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), Staining Methods (StM), Immunostaining (ISt)

Klon

RPAX8-1492
  • Bindungsspezifität

    • 27
    • 9
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 60-261

    Spezifität

    Recognizes a protein of 62 kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    Recombinant fragment (around aa 60-261) of human PAX8 protein (exact sequence is proprietary)

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Positive Control: Raji cells. Renal Cell Carcinoma (IHC).

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    PAX8 (Paired Box 8 (PAX8))

    Andere Bezeichnung

    PAX8

    Molekulargewicht

    62kDa

    Gen-ID

    7849

    UniProt

    Q06710

    Pathways

    Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
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