VLDLR Antikörper (C-Term)

Produktnummer ABIN6940886

Der Maus Monoklonal anti-VLDLR Antikörper wird verwendet zum Nachweis von VLDLR in Proben von Human und Ratte. Er wurde validiert für IHC.

Kurzübersicht für VLDLR Antikörper (C-Term) (ABIN6940886)

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser VLDLR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: VLDLR-1337

Produktdetails anti-VLDLR Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: VLDL-Receptor (Very Low Density Lipoprotein Receptor) Antibody

Spezifität: VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human VLDLR fragment from c-terminal

Isotyp: IgG1, lambda

Anwendungsinformationen

Applikationshinweise:

Positive Control: HeLa or U-251 cells. Pancreas, Cerebellum, Heart or Skeletal Muscle.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu VLDLR

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Andere Bezeichnung: VLDLR

Hintergrund:

Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR

Cerebellum, Heart or Skeletal Muscle., HeLa or U-251 cells. Pancreas

Molekulargewicht: 143-161kDa

Gen-ID: 7436, 370422

UniProt: P98155

Pathways: Cellular Response to Molecule of Bacterial Origin