TIMP3 Antikörper (AA 175-211)

Produktnummer ABIN6940740

Produktdetails anti-TIMP3 Antikörper

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Bindungsspezifität: AA 175-211

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMP3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Staining Methods (StM)

Immunogen: The amino acid sequence (aa175-211), used as the immunogen for TIMP3 Ab, is 100% homologous in human, cow, dog and horse, and 94% homologous in Mouse and rat.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Positive Control: Placenta or breast carcinoma.

Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Andere Bezeichnung: TIMP3 (TIMP3 Produkte)

Synonyme: TIMP-3 antikoerper, TIMP3 antikoerper, timp3 antikoerper, HSMRK222 antikoerper, K222 antikoerper, K222TA2 antikoerper, SFD antikoerper, IMP-3 antikoerper, timp3-A antikoerper, Timp-3 antikoerper, metalloproteinase inhibitor 3 antikoerper, TIMP metallopeptidase inhibitor 3 antikoerper, Metalloproteinase inhibitor 3 antikoerper, TIMP metallopeptidase inhibitor 3 L homeolog antikoerper, tissue inhibitor of metalloproteinase 3 antikoerper, CpipJ_CPIJ003282 antikoerper, TIMP3 antikoerper, timp3 antikoerper, Timp3 antikoerper, timp3.L antikoerper

Hintergrund: TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP's inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.

Molekulargewicht: 30kDa

Gen-ID: 7078

UniProt: P35625