ZFYVE28 Antikörper

Produktnummer ABIN6940433

Der Maus Monoklonal anti-ZFYVE28 Antikörper wird verwendet zum Nachweis von ZFYVE28 in Proben von Human. Er wurde validiert für IHC und StM.

Kurzübersicht für ZFYVE28 Antikörper (ABIN6940433)

Target: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ZFYVE28 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Klon: LST2-2426

Produktdetails anti-ZFYVE28 Antikörper

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length human ZFYVE28 protein

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.

Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu ZFYVE28

Target: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Andere Bezeichnung: ZFYVE28

Hintergrund: ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.

Molekulargewicht: 96kDa

Gen-ID: 57732

Pathways: EGFR Signaling Pathway