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NFE2L1 Antikörper

NFE2L1 Reaktivität: Human WB, IHC, StM Wirt: Maus Monoclonal NRF1-2609 unconjugated
Produktnummer ABIN6940224
  • Target Alle NFE2L1 Antikörper anzeigen
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Reaktivität
    • 42
    • 19
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 38
    • 4
    Maus
    Klonalität
    • 39
    • 3
    Monoklonal
    Konjugat
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NFE2L1 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 21
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human NRF1 protein
    Klon
    NRF1-2609
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product NFE2L1 Primärantikörper
  • Applikationshinweise

    Positive Control: Ubiquitous expression, strongest in skeletal muscle.

    Known Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Andere Bezeichnung
    NFE2L1 (NFE2L1 Produkte)
    Synonyme
    LCR-F1 antikoerper, NRF1 antikoerper, TCF11 antikoerper, AA408798 antikoerper, AW212678 antikoerper, Lcrf1 antikoerper, TCF-11 antikoerper, nfe2l1 antikoerper, nuclear factor, erythroid 2 like 1 antikoerper, nuclear factor, erythroid derived 2,-like 1 antikoerper, nuclear factor, erythroid 2-like 1 antikoerper, nuclear factor, erythroid 2 like 1 S homeolog antikoerper, nuclear factor, erythroid 2-like 1a antikoerper, NFE2L1 antikoerper, Nfe2l1 antikoerper, nfe2l1.S antikoerper, nfe2l1a antikoerper
    Hintergrund
    The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.
    Molekulargewicht
    30kDa (bZIP region), 65-120kDa (glycosylated)
    Gen-ID
    4899
    UniProt
    Q16656
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