MUC4 Antikörper (AA 1730-1864)

Produktnummer ABIN6940126

Dieses Anti-MUC4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MUC4 in IHC und StM. Geeignet für Human.

Kurzübersicht für MUC4 Antikörper (AA 1730-1864) (ABIN6940126)

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUC4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Klon: MUC4-3105

Produktdetails anti-MUC4 Antikörper

Bindungsspezifität: AA 1730-1864

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Stomach, Colon or esophagus.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Andere Bezeichnung: MUC4

Hintergrund: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

Molekulargewicht: 235kDa

Gen-ID: 4585

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity