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MHC Class II HLA-DP/DQ/DR Antikörper

Dieses Anti-MHC Class II HLA-DP/DQ/DR-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MHC Class II HLA-DP/DQ/DR in FACS, IF, WB, IHC, Coat, ELISA und StM. Geeignet für Human.
Produktnummer ABIN6939629

Kurzübersicht für MHC Class II HLA-DP/DQ/DR Antikörper (ABIN6939629)

Target

MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Reaktivität

  • 40
  • 1
Human

Wirt

  • 28
  • 12
Maus

Klonalität

  • 40
Monoklonal

Konjugat

  • 15
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser MHC Class II HLA-DP/DQ/DR Antikörper ist unkonjugiert

Applikation

  • 38
  • 27
  • 25
  • 24
  • 20
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), Coating (Coat), ELISA, Staining Methods (StM)

Klon

CR3-43
  • Spezifität

    Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

    Aufreinigung

    Purified by Protein A/G

    Immunogen

    Cells from human tonsil

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Positive Control: Ramos, Raji cells. Tonsil, Spleen or lymph node.

    Known Application: ELISA (For coating use Ab at 2-4 μg/mL, order Ab without BSA),Flow Cytometry (1-2 μg/ million cells), ,Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10mM PBS with 0.05% BSA & 0.05% azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

    Andere Bezeichnung

    HLA-DP, HLA-DQ, HLA-DR

    Molekulargewicht

    36kDa (' chain) and 27kDa (' chain)

    Gen-ID

    3115, 3117, 3122

    UniProt

    P04440, P01908, P01909, P01920, P01903

    Pathways

    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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