Desmoglein 3 Antikörper (AA 379-491)

Produktnummer ABIN6939268

Dieses Anti-Desmoglein 3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Desmoglein 3 in IHC und StM. Geeignet für Human.

Kurzübersicht für Desmoglein 3 Antikörper (AA 379-491) (ABIN6939268)

Target: Desmoglein 3 (DSG3)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmoglein 3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Klon: DSG3-2840

Produktdetails anti-Desmoglein 3 Antikörper

Bindungsspezifität: AA 379-491

Spezifität: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Desmoglein 3

Target: Desmoglein 3 (DSG3)

Andere Bezeichnung: DSG3

Molekulargewicht: 130kDa

Gen-ID: 1830

UniProt: P32926