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LI Cadherin Antikörper (AA 242-418)

Der Maus Monoklonal Anti-LI Cadherin-Antikörper wurde für IHC (f) und FACS validiert. Er ist geeignet, LI Cadherin in Proben von Human zu detektieren.
Produktnummer ABIN6939029

Kurzübersicht für LI Cadherin Antikörper (AA 242-418) (ABIN6939029)

Target

Alle LI Cadherin Antikörper anzeigen
LI Cadherin

Reaktivität

  • 54
  • 10
  • 8
  • 7
Human

Wirt

  • 36
  • 15
  • 5
Maus

Klonalität

  • 31
  • 20
  • 3
Monoklonal

Konjugat

  • 43
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LI Cadherin Antikörper ist unkonjugiert

Applikation

  • 33
  • 29
  • 19
  • 10
  • 9
  • 8
  • 7
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS)

Klon

CDH17-2618
  • Bindungsspezifität

    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 242-418

    Spezifität

    It recognizes a protein of 120 kDa, which is identified as Cadherin 17 (also known as LI Cadherin). The cadherins are a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

    Kreuzreaktivität (Details)

    Human,

    Aufreinigung

    200ug/ml of Ab Purified from rabbit anti-serum by Protein A.

    Immunogen

    Recombinant fragment (around aa 242-418) of human Cadherin 17 protein (CDH17) (exact sequence is proprietary)

    Isotyp

    IgG2b
  • Applikationshinweise

    Positive Control: MCF-7, HepG2 or HT29 cells. Stomach, Small Intestine, Colon or liver.

    Known Application: Flow Cytometry (1-2 μg/million cells),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

    Haltbarkeit

    24 months
  • Target

    LI Cadherin

    Andere Bezeichnung

    CDH17

    Hintergrund

    BILL-cadherin, Cadherin-17, CDH17, HPT-1 cadherin, human intestinal peptide-associated transporter HPT-1, human peptide transporter 1 (HPT-1), Intestinal peptide-associated transporter HPT-1, LI-cadherin (liver-intestine), Liver Cadherin, Liver-intestine cadherin,Cadherin 17 / LI Cadherin (Liver-Intestine Marker)
    Cellular localisation: Cell Surface and Cytoplasmic

    Molekulargewicht

    120kDa

    Gen-ID

    1015, 591853

    UniProt

    Q12864
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