TIMP1 Antikörper (AA 72-82)

Produktnummer ABIN6938575

Dieses Anti-TIMP1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TIMP1 in ELISA und Coat. Geeignet für Human.

Kurzübersicht für TIMP1 Antikörper (AA 72-82) (ABIN6938575)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIMP1 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Klon: 2A5

Produktdetails anti-TIMP1 Antikörper

Bindungsspezifität: AA 72-82

Spezifität: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: A synthetic peptide (aa 72-82) of human TIMP1 protein (FQALGDAADIR)

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: 293 cells. Colon Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu TIMP1

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Andere Bezeichnung: TIMP1

Hintergrund: Collagenase inhibitor, EPO, Erythroid-Potentiating Activity (EPA), Fibroblast collagenase inhibitor, Human Collagenase Inhibitor (HCI), Metalloproteinase inhibitor 1, Tissue Inhibitor of Metalloproteinase 1 (TIMP1),TIMP1 (Marker of Lymph Node Metastasis)
Cellular localisation: Cytoplasmic and Secreted

Molekulargewicht: 23kDa

Gen-ID: 7076, 522632

UniProt: P01033