Rekombinanter Thrombomodulin Antikörper (AA 69-194)

Produktnummer ABIN6938551

Produktdetails anti-Thrombomodulin Antikörper

Target: Thrombomodulin (THBD)

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: AA 69-194

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thrombomodulin Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat), Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: It recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi's sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 69-194) of human Thrombomodulin (CD141) protein (exact sequence is proprietary)

Klon: RTHBD-1591

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris buffer with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: THP1 cells. Placenta, Angiosarcoma, Bladder or Cervical Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Thrombomodulin

Target: Thrombomodulin (THBD)

Andere Bezeichnung: THBD (THBD Produkte)

Synonyme: AHUS6 antikoerper, BDCA3 antikoerper, CD141 antikoerper, THPH12 antikoerper, THRM antikoerper, TM antikoerper, AI385582 antikoerper, THBD antikoerper, HAST antikoerper, HAST3 antikoerper, M-PST antikoerper, ST1A3/ST1A4 antikoerper, ST1A5 antikoerper, STM antikoerper, TL-PST antikoerper, thrombomodulin antikoerper, sulfotransferase family 1A member 3 antikoerper, THBD antikoerper, Thbd antikoerper, SULT1A3 antikoerper

Hintergrund: AHUS6, BDCA3, CD141, Fetomodulin, Thbd, THPH12, THRM, Thrombomodulin (TM),Thrombomodulin / CD141 (Endothelial Cell Marker)
Cellular localisation: Cell Surface & Cytoplasmic

Molekulargewicht: ~100kDa

Gen-ID: 7056, 2030

UniProt: P07204