s100a4 Antikörper
-
- Target Alle s100a4 (S100A4) Antikörper anzeigen
- s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))
-
Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser s100a4 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)
- Spezifität
- S100A4 belongs to the S100 super-family of proteins containing 2 EF-hand calcium-binding domains. S100A4 has been implicated in the progression and prognosis of several forms of human cancer, e.g. breast, colorectal, gastric, pancreatic and bladder cancer, SCLC and oesophageal squamous cell carcinoma, among others. Poor prognosis associated with high S100A4 expression is accompanied by clear signs of disease progression, e.g. high histological and clinical grades and involvement of lymph nodes.Also indicative of poor prognosis is high S100A4 expression coupled with reduced E-cadherin expression in pancreatic, oral squamous cell carcinoma and in melanoma. S100A4 expression is inversely related with expression of metastasis suppressor nm23 and with prognosis of breast cancer. S100A4 is overexpressed in highly metastatic cancers, which makes it useful as a marker of tumor progression.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human S100A4 full length protein
- Klon
- CPTC-S100A4-3
- Isotyp
- IgG2c kappa
- Top Product
- Discover our top product S100A4 Primärantikörper
-
-
- Applikationshinweise
-
Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: T98G, HeLa, A549 or A375 cells. Placenta, small intestine.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
-
- Target
- s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))
- Andere Bezeichnung
- S100A4 (S100A4 Produkte)
- Synonyme
- 18A2 antikoerper, 42A antikoerper, CAPL antikoerper, FSP1 antikoerper, MTS1 antikoerper, P9KA antikoerper, PEL98 antikoerper, 42a antikoerper, Capl antikoerper, FSp1 antikoerper, Mts1 antikoerper, PeL98 antikoerper, metastasin antikoerper, pk9a antikoerper, S100A4 antikoerper, P9ka antikoerper, RNP9KA antikoerper, S100 calcium binding protein A4 antikoerper, S100 calcium-binding protein A4 antikoerper, S100A4 antikoerper, S100a4 antikoerper
- Hintergrund
-
S100 calcium-binding protein A4, Calvasculin, CAPL, Fibroblast specific protein 1 (FSP1), Leukemia multidrug resistance associated protein, Malignant transformation suppression 1 (MTS1), Metastasin, Placental calcium-binding protein,S100A4 / Metastasin / Calvasculin (Marker of Tumor Metastasis)
Cellular localisation: Nucleus and cytoplasm. - Molekulargewicht
- 12kDa
- Gen-ID
- 6275, 654444
- UniProt
- P26447
- Pathways
- S100 Proteine
-