PDCD1LG2 Antikörper (AA 27-220)

Produktnummer ABIN6938140

Produktdetails anti-PDCD1LG2 Antikörper

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Bindungsspezifität: AA 27-220

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDCD1LG2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)

Klon: PDL2-1850

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.

Positive_Control: Placenta or Pancreas. Thyroid Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu PDCD1LG2

Target: PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))

Andere Bezeichnung: PDCD1LG2 (PDCD1LG2 Produkte)

Synonyme: PDL2 antikoerper, B7DC antikoerper, Btdc antikoerper, CD273 antikoerper, PD-L2 antikoerper, PDCD1L2 antikoerper, bA574F11.2 antikoerper, B7-DC antikoerper, F730015O22Rik antikoerper, programmed cell death 1 ligand 2 antikoerper, PDCD1LG2 antikoerper, Pdcd1lg2 antikoerper

Hintergrund: B7 dendritic cell molecule, B7-DC, B7DC, Btdc, Butyrophilin B7DC, CD273, PD-L2, PDCD1L2, PDCD1LG2, PDL2, Programmed death ligand 2,PD-L2 / PDCD1LG2 / CD273
Cellular localisation: Cytoplasmic and Cell Surface

Molekulargewicht: 31kDa

Gen-ID: 80380, 532279, 617872