PAX2A Antikörper (AA 223-354)

Produktnummer ABIN6938116

Produktdetails anti-PAX2A Antikörper

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Bindungsspezifität: AA 223-354

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAX2A Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: Recognizes a protein of 42kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 223-354) human PAX2 protein (exact sequence is proprietary)

Klon: PAX2-1104

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: NAMALWA cells. Fetal kidney or Renal Cell Carcinoma (RCC) or Ovarian Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu PAX2A

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Andere Bezeichnung: PAX2 (PAX2A Produkte)

Synonyme: PAPRS antikoerper, Opdc antikoerper, Pax-2 antikoerper, Pax-2a antikoerper, XPax-2 antikoerper, XPax2 antikoerper, pax-2 antikoerper, pax2 antikoerper, xPax-2a antikoerper, PAXZF-B antikoerper, cb378 antikoerper, noi antikoerper, pax-b antikoerper, pax2.1 antikoerper, pax2a1 antikoerper, pax[zf-b] antikoerper, paxb antikoerper, pax2.2 antikoerper, paired box 2 antikoerper, paired box 2 L homeolog antikoerper, paired box 2a antikoerper, paired box 2b antikoerper, PAX2 antikoerper, Pax2 antikoerper, pax2.L antikoerper, pax2a antikoerper, pax2b antikoerper

Hintergrund: Paired box gene 2, paired box homeotic gene 2, paired box protein 2, Paired box protein Pax-2, Paired box protein Pax2,PAX2 (Renal Cell & Ovarian Carcinoma Marker)
Cellular localisation: Nuclear

Molekulargewicht: 42kDa

Gen-ID: 5076, 155644

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation