MUC4 Antikörper (AA 1730-1864)

Produktnummer ABIN6937955

Produktdetails anti-MUC4 Antikörper

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Bindungsspezifität: AA 1730-1864

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUC4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)

Klon: MUC4-3105

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Stomach, Colon or esophagus.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu MUC4

Target: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Andere Bezeichnung: MUC4 (MUC4 Produkte)

Synonyme: 4933405I11Rik antikoerper, Asgp antikoerper, ASGP antikoerper, HSA276359 antikoerper, MUC-4 antikoerper, ASGP-1 antikoerper, Psmc antikoerper, mucin 4 antikoerper, mucin 4, cell surface associated antikoerper, Muc4 antikoerper, MUC4 antikoerper

Hintergrund: Ascites sialoglycoprotein 1, Ascites sialoglycoprotein 2, Ascites sialoglycoprotein, ASGP, ASGP-1, ASGP-2, Mucin 4 cell surface associated, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin,MUC4 (Mucin 4 / Gastric Mucin)
Cellular localisation: Cytoplasmic

Molekulargewicht: 235kDa

Gen-ID: 4585, 369646

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity