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Cytokeratin 5 Antikörper (AA 316-590)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Cytokeratin 5 in IHC und IHC (f). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6937712

Kurzübersicht für Cytokeratin 5 Antikörper (AA 316-590) (ABIN6937712)

Target

Alle Cytokeratin 5 (KRT5) Antikörper anzeigen
Cytokeratin 5 (KRT5) (Keratin 5 (KRT5))

Reaktivität

  • 147
  • 85
  • 57
  • 12
  • 11
  • 11
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 108
  • 53
  • 2
Maus

Klonalität

  • 93
  • 70
Monoklonal

Konjugat

  • 73
  • 17
  • 12
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Cytokeratin 5 Antikörper ist unkonjugiert

Applikation

  • 102
  • 76
  • 47
  • 32
  • 30
  • 27
  • 18
  • 14
  • 13
  • 13
  • 10
  • 9
  • 6
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon

KRT5-3594
  • Bindungsspezifität

    • 16
    • 16
    • 15
    • 11
    • 9
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 316-590

    Spezifität

    This MAb recognizes a protein of 58 kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Antibodies to KRT5 identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas express.Anti-KRT5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast, glandular epithelia, and basal cells of the prostate are labeled with anti-KRT5.

    Kreuzreaktivität (Details)

    Human.

    Aufreinigung

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    Recombinant fragment (around aa 316-590) of human Cytokeratin 5 (KRT5) protein (exact sequence is proprietary)

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: MCF-7 or HeLa cells. Human tonsil, esophagus or bladder tissue (IHC).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Konservierungsmittel

    Azide free

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Haltbarkeit

    24 months
  • Target

    Cytokeratin 5 (KRT5) (Keratin 5 (KRT5))

    Andere Bezeichnung

    KRT5

    Hintergrund

    58 kDa Cytokeratin, DDD1, Epidermolysis Bullosa Simplex 2 (EBS2), Keratin 5, Keratin, Type II Cytoskeletal 5, Keratin-5, Type-II Cytoskeletal 5, Type-II keratin Kb5,Cytokeratin 5 (KRT5) (Basal, Myoepithelial & Mesothelial Cell Marker)
    Cellular localisation: Cytoplasmic

    Molekulargewicht

    58kDa

    Gen-ID

    3852, 433845

    UniProt

    P13647
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