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IGHG4 Antikörper

IGHG4 Reaktivität: Human ISt, IHC (f) Wirt: Maus Monoclonal IGHG4-1345 unconjugated
Produktnummer ABIN6937504
  • Target Alle IGHG4 Produkte
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Reaktivität
    • 15
    • 1
    • 1
    Human
    Wirt
    • 11
    • 4
    Maus
    Klonalität
    • 10
    • 5
    Monoklonal
    Konjugat
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IGHG4 Antikörper ist unkonjugiert
    Applikation
    • 10
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant human IGHG4 fragment
    Klon
    IGHG4-1345
    Isotyp
    IgG1 kappa
  • Applikationshinweise

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: Tonsil.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Andere Bezeichnung
    IGHG4 (IGHG4 Produkte)
    Synonyme
    immunoglobulin heavy constant gamma 4 (G4m marker) antikoerper, IGHG4 antikoerper
    Hintergrund
    Ig gamma 4 chain C region, IGHG4, Immunoglobulin heavy constant gamma 4 (G4m marker),IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker)
    Cellular localisation: Cytoplasmic
    Molekulargewicht
    150kDa
    Gen-ID
    3503, 510635
    UniProt
    P01861
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