Human Papilloma Virus 16 E2 (HPV-16 E2) Antikörper

Produktnummer ABIN6937435

Der Maus Monoklonal anti-Human Papilloma Virus 16 E2 Antikörper (Klon TVG 261) (ABIN6937435) detektiert spezifisch Human Papilloma Virus 16 E2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human Papillomavirus 16 (HPV-16).

Kurzübersicht für Human Papilloma Virus 16 E2 (HPV-16 E2) Antikörper (ABIN6937435)

Target: Human Papilloma Virus 16 E2 (HPV-16 E2)

Reaktivität: Human Papillomavirus 16 (HPV-16)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Klon: TVG 261

Produktdetails

Aufreinigung: Purified by Protein A/G

Immunogen: Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: HPV-16 infected cells. Cervical tissue.

Known Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 10 mM PBS without BSA and without Azide.

Konservierungsmittel: Azide free

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.

Haltbarkeit: 24 months

Antigendetails

Target: Human Papilloma Virus 16 E2 (HPV-16 E2)

Andere Bezeichnung: HPV16 E2 (Human Papilloma Virus 16)

Substanzklasse: Viral Protein

Hintergrund: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome.

Molekulargewicht: 43kDa